Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls


Booiman T, Wit FW, Girigorie AF, Maurer I, De Francesco D, Sabin CA, Harskamp AM, Prins M, Franceschi C, Deeks SG, Winston A, Reiss P, Kootstra NA.

Lay summary

It is often reported that people with HIV on effective treatment continue to have immune systems that are activated and that this contributes to the development of co-morbidities as people get older.  We compared several markers of immune activation and inflammation in the blood among people with and without HIV in the COBRA study and also to a group of blood donors in the Netherlands.  Although we found large differences between the measurements in people with HIV and those in the blood donors, we found similar differences between the measurements in the people without HIV in COBRA and the

Research theme