The ‘ComorBidity in Relation to AIDS’ (COBRA) cohort: design, methods and participant characteristics


De Francesco D, Wit FW, Cole JH, Kootstra NA, Winston A, Sabin CA, Underwood J, van Zoest RA, Schouten J, Kooij KW, Prins M, Guaraldi G, Caan MWA, Burger D, Franceschi C, Libert C, Bürkle A, Reiss P.

Lay summary

This paper describes the design and set-up of the COmorBidity in Relation to AIDS (COBRA) Study.  The study includes 134 older people with HIV (including 59 POPPY participants) and 79 people without HIV of a similar age (29 POPPY participants).  The paper provides a description of the characteristics of these people and compares them to the larger group of people who are in the ‘parent’ studies (POPPY in the UK, and the AGEhiV study in the Netherlands).  The characteristics of the COBRA participants were broadly similar to those of the bigger groups, suggesting that any study findings will

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